BCPS BCPS Cardiovascular & Specialty Pharmacotherapy 3

Question 1

Which drug used for osteoporosis works by inhibiting RANK ligand, thereby reducing osteoclast activity?

Accepted Answer

Denosumab (RANK-L inhibitor)

Answer

Alendronate (bisphosphonate)

Answer

Teriparatide (PTH analog)

Answer

Raloxifene (SERM)

Question 2

A patient with gout has a uric acid level of 9.8 mg/dL despite dietary changes. Which urate-lowering agent is first-line for chronic gout prevention?

Accepted Answer

Allopurinol

Answer

Colchicine

Answer

Indomethacin

Answer

Probenecid

Question 3

Which inhaled medication is the preferred first-line controller therapy for mild persistent asthma in adults?

Accepted Answer

Inhaled corticosteroid (ICS) such as fluticasone

Answer

Short-acting beta-agonist (SABA) as needed only

Answer

Long-acting beta-agonist (LABA) monotherapy

Answer

Leukotriene receptor antagonist monotherapy

Question 4

A patient with COPD and frequent exacerbations (≥2/year) despite LAMA monotherapy should have which agent added to their regimen?

Accepted Answer

LABA + ICS combination

Answer

Inhaled corticosteroid (ICS)

Answer

Short-acting muscarinic antagonist (SAMA)

Answer

Long-acting beta-agonist (LABA)

Question 5

Which pain management approach is recommended first-line for mild-to-moderate osteoarthritis pain before considering opioids or COX-2 inhibitors?

Accepted Answer

Acetaminophen or topical NSAIDs

Answer

Opioid analgesics (e.g., oxycodone)

Answer

Oral COX-2 inhibitor (celecoxib)

Answer

Systemic corticosteroids

Question 6

A patient on warfarin for mechanical heart valve is started on amiodarone for atrial fibrillation. What pharmacokinetic interaction requires dose adjustment?

Accepted Answer

Amiodarone inhibits CYP2C9 and CYP3A4, increasing warfarin effect and INR

Answer

Amiodarone induces CYP2C9, decreasing warfarin levels

Answer

Amiodarone reduces warfarin absorption

Answer

Amiodarone has no significant interaction with warfarin