Insulin Therapy Flashcards
7 cards from real BC ADM practice questions. Tap to flip, then mark Knew It or Still Learning — missed cards come back until you master them.
Read the first 7 Insulin Therapy flashcards as text
A patient on U-500 regular insulin requires dose conversion when switching to U-100 insulin. Which statement is correct regarding this transition?
Answer: Divide the U-500 dose by 5 to get the equivalent U-100 units
U-500 is 5 times more concentrated than U-100, so dividing the U-500 unit dose by 5 gives the equivalent number of units in U-100.
Which insulin formulation provides the most consistent and predictable absorption with the least intra-patient variability?
Answer: Insulin glargine U-300
Insulin glargine U-300 (Toujeo) demonstrates the least intra-patient pharmacokinetic variability among basal insulins due to its concentrated depot formation.
A patient with type 1 diabetes uses a total daily dose (TDD) of 40 units. Using the 500 rule, what is the estimated insulin sensitivity factor (ISF)?
Answer: 12.5 mg/dL per unit
The 500 rule: 500 ÷ TDD = ISF; 500 ÷ 40 = 12.5 mg/dL drop per unit of rapid-acting insulin.
When initiating basal insulin in a person with type 2 diabetes, which titration approach is supported by clinical evidence?
Answer: Increase by 2 units every 3 days until fasting glucose is 80–130 mg/dL
The treat-to-target approach of increasing basal insulin by 2 units every 3 days until fasting glucose reaches 80–130 mg/dL is well-validated (e.g., INSIGHT trial).
A patient develops lipohypertrophy at their preferred injection site. Which consequence is most clinically relevant?
Answer: Unpredictable insulin absorption causing glucose variability
Lipohypertrophy alters insulin absorption kinetics, resulting in erratic uptake and unpredictable blood glucose excursions.
Which of the following best describes the pharmacokinetic difference between insulin aspart and regular human insulin?
Answer: Aspart has a faster onset and shorter duration than regular insulin
Insulin aspart (rapid-acting) has an onset of ~15 min and duration of 3–5 hours, versus regular insulin onset of 30–60 min and duration of 5–8 hours.
In a closed-loop insulin delivery system, the algorithm primarily adjusts which insulin component to maintain glucose in range?
Answer: Basal insulin rate based on continuous glucose sensor readings
Closed-loop (artificial pancreas) systems automatically modulate the basal insulin infusion rate in response to real-time CGM data to maintain glycemic targets.