Practice Test Geeks(BC ADM) Advanced Diabetes Management Certification Practice Test
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Fundamentals & Core Concepts Flashcards

7 cards from real BC ADM practice questions. Tap to flip, then mark Knew It or Still Learning — missed cards come back until you master them.

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  1. Which enzyme is responsible for converting proinsulin to insulin in the pancreatic beta cell?

    Answer: Prohormone convertases PC1/3 and PC2 along with carboxypeptidase E

    Proinsulin is cleaved to insulin and C-peptide by prohormone convertases PC1/3 and PC2, with carboxypeptidase E removing residual amino acids.

  2. The Somogyi effect refers to which glucose pattern?

    Answer: Rebound hyperglycemia following nocturnal hypoglycemia

    The Somogyi effect (rebound hyperglycemia) occurs when nocturnal hypoglycemia triggers counterregulatory hormones, causing morning high glucose.

  3. In type 1 diabetes, the autoimmune destruction of beta cells is primarily mediated by which immune mechanism?

    Answer: CD8+ cytotoxic T lymphocytes acting directly on beta cells

    CD8+ cytotoxic T lymphocytes are the primary effectors of beta-cell destruction in type 1 diabetes, recognizing beta-cell autoantigens presented on MHC class I.

  4. Glucokinase (hexokinase IV) acts as the glucose sensor in pancreatic beta cells because it:

    Answer: Has a high Km and is not saturated at normal glucose levels

    Glucokinase has a high Km (~10 mM) so its activity rises proportionally with glucose concentration, allowing beta cells to sense physiologic glucose changes.

  5. Which statement best describes C-peptide's clinical utility in diabetes management?

    Answer: It measures residual beta-cell function and helps distinguish insulin deficiency types

    C-peptide is an indirect marker of endogenous insulin secretion, used to assess residual beta-cell function and differentiate type 1 from type 2 diabetes.

  6. A patient with a fasting plasma glucose of 118 mg/dL on two separate occasions is classified as having:

    Answer: Impaired fasting glucose (prediabetes)

    Impaired fasting glucose (prediabetes) is defined by fasting plasma glucose of 100–125 mg/dL on two occasions per ADA criteria.

  7. Which lipoprotein abnormality is most characteristically associated with insulin resistance in type 2 diabetes?

    Answer: Low HDL-C, elevated triglycerides, and small dense LDL particles

    Insulin resistance promotes atherogenic dyslipidemia characterized by elevated triglycerides, low HDL-C, and small dense LDL, increasing cardiovascular risk.