Comprehensive Diabetes Assessment & Diagnosis Flashcards
7 cards from real BC ADM practice questions. Tap to flip, then mark Knew It or Still Learning — missed cards come back until you master them.
Read the first 7 Comprehensive Diabetes Assessment & Diagnosis flashcards as text
A 34-year-old non-obese woman of South Asian descent is diagnosed with diabetes. GCK mutation is identified on genetic testing. Which subtype does she have?
Answer: MODY 2 (GCK-MODY)
GCK-MODY (MODY 2) is caused by heterozygous glucokinase mutations that raise the glucose set-point, causing mild stable hyperglycemia that rarely requires pharmacotherapy.
Which symptom is most characteristic of hyperosmolar hyperglycemic state (HHS) at presentation compared to diabetic ketoacidosis?
Answer: Profound dehydration with minimal to no ketosis
HHS is characterized by extreme hyperglycemia (often >600 mg/dL), severe dehydration, and hyperosmolality without significant ketoacidosis.
Which HbA1c value meets the ADA diagnostic threshold for diabetes in the absence of hyperglycemic symptoms?
Answer: ≥6.5%
HbA1c ≥6.5% on two separate tests (or once with confirmatory testing) meets ADA criteria for diagnosing diabetes.
A patient reports episodes of sweating, tremor, and confusion 3 hours after meals. Post-prandial glucose at 3 hours is 48 mg/dL. What condition should be evaluated?
Answer: Reactive hypoglycemia / postprandial hypoglycemia
Reactive hypoglycemia presents with adrenergic and neuroglycopenic symptoms 2–5 hours after a meal, confirmed by low glucose during symptoms.
Which laboratory finding distinguishes latent autoimmune diabetes in adults (LADA) from classic type 2 diabetes?
Answer: Presence of GAD65 autoantibodies with low C-peptide
Positive GAD65 autoantibodies combined with declining C-peptide distinguishes LADA from type 2 diabetes and signals eventual insulin dependence.
In assessing diabetes management quality, time-in-range (TIR) refers to the percentage of CGM readings between which glucose values?
Answer: 70–180 mg/dL
International consensus defines TIR as the percentage of time glucose remains within 70–180 mg/dL for most non-pregnant adults with diabetes.
A 55-year-old man with type 2 diabetes has an eGFR of 38 mL/min/1.73m². Which drug class requires dose adjustment or discontinuation at this level?
Answer: Metformin
Metformin is contraindicated when eGFR falls below 30 and should be used cautiously with dose adjustment when eGFR is 30–45 due to lactic acidosis risk.