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Comprehensive Diabetes Assessment & Diagnosis Flashcards

7 cards from real BC ADM practice questions. Tap to flip, then mark Knew It or Still Learning — missed cards come back until you master them.

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  1. A 34-year-old non-obese woman of South Asian descent is diagnosed with diabetes. GCK mutation is identified on genetic testing. Which subtype does she have?

    Answer: MODY 2 (GCK-MODY)

    GCK-MODY (MODY 2) is caused by heterozygous glucokinase mutations that raise the glucose set-point, causing mild stable hyperglycemia that rarely requires pharmacotherapy.

  2. Which symptom is most characteristic of hyperosmolar hyperglycemic state (HHS) at presentation compared to diabetic ketoacidosis?

    Answer: Profound dehydration with minimal to no ketosis

    HHS is characterized by extreme hyperglycemia (often >600 mg/dL), severe dehydration, and hyperosmolality without significant ketoacidosis.

  3. Which HbA1c value meets the ADA diagnostic threshold for diabetes in the absence of hyperglycemic symptoms?

    Answer: ≥6.5%

    HbA1c ≥6.5% on two separate tests (or once with confirmatory testing) meets ADA criteria for diagnosing diabetes.

  4. A patient reports episodes of sweating, tremor, and confusion 3 hours after meals. Post-prandial glucose at 3 hours is 48 mg/dL. What condition should be evaluated?

    Answer: Reactive hypoglycemia / postprandial hypoglycemia

    Reactive hypoglycemia presents with adrenergic and neuroglycopenic symptoms 2–5 hours after a meal, confirmed by low glucose during symptoms.

  5. Which laboratory finding distinguishes latent autoimmune diabetes in adults (LADA) from classic type 2 diabetes?

    Answer: Presence of GAD65 autoantibodies with low C-peptide

    Positive GAD65 autoantibodies combined with declining C-peptide distinguishes LADA from type 2 diabetes and signals eventual insulin dependence.

  6. In assessing diabetes management quality, time-in-range (TIR) refers to the percentage of CGM readings between which glucose values?

    Answer: 70–180 mg/dL

    International consensus defines TIR as the percentage of time glucose remains within 70–180 mg/dL for most non-pregnant adults with diabetes.

  7. A 55-year-old man with type 2 diabetes has an eGFR of 38 mL/min/1.73m². Which drug class requires dose adjustment or discontinuation at this level?

    Answer: Metformin

    Metformin is contraindicated when eGFR falls below 30 and should be used cautiously with dose adjustment when eGFR is 30–45 due to lactic acidosis risk.