B.Pharm. Bachelor of Pharmacy Biopharmaceutics & Pharmacokinetics 2

Question 1

The therapeutic index (TI) of a drug is defined as the ratio of:

Accepted Answer

LD50 to ED50

Answer

ED50 to LD50

Answer

Cmax to Cmin

Answer

AUC to half-life

Question 2

Zero-order kinetics means that the rate of drug elimination is:

Accepted Answer

Constant and independent of plasma drug concentration

Answer

Proportional to plasma drug concentration

Answer

Exponential over time

Answer

Dependent on protein binding

Question 3

The absorption rate constant (Ka) is used to describe:

Accepted Answer

The speed at which a drug is absorbed from the site of administration into systemic circulation

Answer

The rate of drug distribution into tissues

Answer

The rate of renal drug excretion

Answer

The rate of hepatic drug metabolism

Question 4

The Area Under the Curve (AUC) in pharmacokinetics represents:

Accepted Answer

Total drug exposure over time

Answer

Peak plasma drug concentration

Answer

Volume of drug distribution

Answer

Rate of drug clearance

Question 5

Highly plasma protein-bound drugs have a characteristically:

Accepted Answer

Small volume of distribution and prolonged half-life

Answer

Large volume of distribution and short half-life

Answer

Rapid renal clearance and high free fraction

Answer

Low bioavailability and fast onset

Question 6

Enterohepatic circulation involves the recycling of drugs or metabolites through the:

Accepted Answer

Liver, bile, intestine, and portal vein

Answer

Kidney and bladder loop

Answer

Lung and pulmonary circulation

Answer

Lymph and thoracic duct

Question 7

A drug with a volume of distribution (Vd) of 200 L in a 70 kg person suggests the drug is:

Accepted Answer

Extensively distributed into peripheral tissues

Answer

Confined mainly to the plasma

Answer

Bound primarily to albumin in blood

Answer

Eliminated rapidly by the kidneys