Bachelor of Pharmacy (B.Pharm.) Pharmaceutics Flashcards
7 cards from real B.Pharm. Bachelor of Pharmacy practice questions. Tap to flip, then mark Knew It or Still Learning — missed cards come back until you master them.
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The Biopharmaceutics Classification System (BCS) Class II drugs have:
Answer: Low solubility and high permeability
BCS Class II drugs are poorly soluble but highly permeable; dissolution is the rate-limiting step for absorption.
Which sterilization method is most appropriate for thermolabile ophthalmic solutions?
Answer: Filtration through a 0.22 µm membrane
Membrane filtration (0.22 µm) removes microorganisms without heat, preserving thermolabile drug integrity.
In a two-compartment pharmacokinetic model, the initial rapid decline in plasma drug concentration after IV bolus represents:
Answer: Distribution of drug from central to peripheral compartment
The alpha (distribution) phase reflects rapid drug transfer from plasma into peripheral tissues following IV injection.
Crospovidone (cross-linked PVP) is classified as a:
Answer: Superdisintegrant
Crospovidone rapidly wicks water and swells, functioning as a superdisintegrant to facilitate tablet breakup.
The critical micellar concentration (CMC) is the surfactant concentration above which:
Answer: Micelles spontaneously form in solution
Above the CMC, surfactant monomers aggregate into micelles, dramatically improving solubilization of lipophilic drugs.
In lyophilization (freeze-drying), the primary drying step involves removal of:
Answer: Free ice by sublimation under vacuum
Primary drying sublimates free frozen water directly from ice to vapor under reduced pressure without melting.
Which route of drug administration completely bypasses first-pass metabolism?
Answer: Sublingual
Sublingual administration allows drug to absorb directly into systemic circulation via the sublingual veins, bypassing the liver.