Bachelor of Pharmacy (B.Pharm.) Pharmaceutics Flashcards
7 cards from real B.Pharm. Bachelor of Pharmacy practice questions. Tap to flip, then mark Knew It or Still Learning — missed cards come back until you master them.
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Which rheological property describes a fluid whose viscosity decreases under shear stress but recovers when stress is removed?
Answer: Thixotropy
Thixotropy refers to a reversible, time-dependent decrease in viscosity upon application of shear stress.
The Henderson-Hasselbalch equation is primarily used in pharmacy to calculate:
Answer: pH of buffer systems
The Henderson-Hasselbalch equation relates pH, pKa, and the ratio of conjugate base to acid in a buffer.
Which type of emulsion is preferred for intravenous administration of lipophilic drugs?
Answer: Oil-in-water (O/W)
O/W emulsions place oil droplets in a continuous aqueous phase, making them compatible with blood for IV use.
Fick's first law of diffusion states that the rate of drug permeation is directly proportional to:
Answer: Concentration gradient
Fick's first law: flux = -D × (dC/dx), showing flux is proportional to the concentration gradient.
Supercritical fluid technology using CO₂ is most commonly applied in pharmaceutical manufacturing to:
Answer: Micronize drug particles
Supercritical CO₂ is used in particle engineering (RESS, SAS processes) to produce fine, uniform drug particles.
The term 'apparent volume of distribution' (Vd) exceeding total body water (~42 L in a 70 kg adult) indicates that the drug:
Answer: Partitions significantly into tissues
A large Vd indicates extensive tissue distribution and sequestration outside the vascular compartment.
Which preservative system is most commonly used in ophthalmic preparations to prevent microbial contamination?
Answer: Benzalkonium chloride
Benzalkonium chloride (BAK) is the most widely used preservative in ophthalmic drops due to its broad-spectrum activity.