Bachelor of Pharmacy (B.Pharm.) Pharmaceutical Chemistry Flashcards
7 cards from real B.Pharm. Bachelor of Pharmacy practice questions. Tap to flip, then mark Knew It or Still Learning — missed cards come back until you master them.
Read the first 7 Bachelor of Pharmacy (B.Pharm.) Pharmaceutical Chemistry flashcards as text
What is the significance of the Henderson-Hasselbalch equation in pharmacy?
Answer: It predicts the ratio of ionized to unionized drug at a given pH based on pKa
The Henderson-Hasselbalch equation (pH = pKa + log([A⁻]/[HA])) predicts drug ionization state, which governs membrane permeability and absorption.
Which type of isomerism exists between glucose and fructose?
Answer: Constitutional (structural) isomerism
Glucose and fructose are constitutional isomers — both have the molecular formula C₆H₁₂O₆ but differ in the position of their carbonyl group (aldehyde vs. ketone).
In pharmaceutical quality control, what does the term 'limit test for heavy metals' primarily detect?
Answer: Trace amounts of lead and other toxic metals in drug substances
The limit test for heavy metals detects trace toxic metals (primarily lead) in drug substances using precipitation with hydrogen sulfide or sodium sulfide.
What is the chemical basis of chelation therapy using EDTA (ethylenediaminetetraacetic acid)?
Answer: EDTA forms stable, water-soluble complexes with metal ions, facilitating their excretion
EDTA is a hexadentate chelating agent that forms stable, water-soluble coordination complexes with metal ions, enabling renal elimination.
Which pharmacokinetic parameter describes the volume of plasma cleared of drug per unit time?
Answer: Clearance (CL)
Clearance (CL) represents the volume of plasma from which a drug is completely removed per unit time, reflecting the efficiency of drug elimination.
What is the role of a preservative such as benzalkonium chloride in ophthalmic pharmaceutical preparations?
Answer: To prevent microbial contamination and maintain sterility during use
Benzalkonium chloride is a quaternary ammonium preservative that disrupts microbial cell membranes, preventing contamination in multi-dose ophthalmic products.
Which reaction type is involved when an amino acid forms a peptide bond with another amino acid?
Answer: Condensation (dehydration) reaction
Peptide bond formation is a condensation reaction where the carboxyl group of one amino acid reacts with the amino group of another, releasing water.