Bachelor of Pharmacy (B.Pharm.) Biochemistry Flashcards
7 cards from real B.Pharm. Bachelor of Pharmacy practice questions. Tap to flip, then mark Knew It or Still Learning — missed cards come back until you master them.
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In oxidative phosphorylation, the proton gradient across the inner mitochondrial membrane drives ATP synthesis via which complex?
Answer: Complex V (ATP synthase)
Complex V (ATP synthase/F0F1-ATPase) harnesses the proton-motive force to phosphorylate ADP to ATP through rotary catalysis.
Transamination reactions require which coenzyme derived from vitamin B6?
Answer: Pyridoxal phosphate (PLP)
Pyridoxal phosphate forms a Schiff base with the amino acid substrate and shuttles the amino group between donors and α-ketoglutarate in transamination.
Which metabolic pathway is exclusively located in the cytosol of eukaryotic cells?
Answer: Glycolysis
All ten enzymatic steps of glycolysis occur in the cytoplasm; the other pathways listed are mitochondrial.
What is the role of feedback inhibition by CTP on aspartate transcarbamoylase (ATCase) in pyrimidine biosynthesis?
Answer: It inhibits ATCase to prevent overproduction of pyrimidines
CTP, the end product of pyrimidine synthesis, allosterically inhibits ATCase at the regulatory subunit, providing classic feedback regulation.
Which lipoprotein is primarily responsible for transporting dietary triglycerides from the intestine to peripheral tissues?
Answer: Chylomicrons
Chylomicrons are assembled in intestinal enterocytes and transport exogenous dietary triglycerides via lymph into the bloodstream to peripheral tissues.
Which enzyme unwinds the DNA double helix ahead of the replication fork?
Answer: DNA helicase
DNA helicase uses ATP hydrolysis to break hydrogen bonds between base pairs and separate the two DNA strands at the replication fork.
The pentose phosphate pathway primarily produces which two products used in biosynthesis?
Answer: NADPH and ribose-5-phosphate
The oxidative branch of the pentose phosphate pathway generates NADPH (for reductive biosynthesis and antioxidant defense) and ribose-5-phosphate (for nucleotide synthesis).