Bachelor of Pharmacy (B.Pharm.) Flashcards
7 cards from real B.Pharm. Bachelor of Pharmacy practice questions. Tap to flip, then mark Knew It or Still Learning — missed cards come back until you master them.
Read the first 7 Bachelor of Pharmacy (B.Pharm.) flashcards as text
A drug with a high first-pass effect is best administered via which route to maximize bioavailability?
Answer: Sublingual
Sublingual administration bypasses the portal circulation, avoiding first-pass hepatic metabolism and achieving higher systemic bioavailability.
What is the primary pharmacological action of HMG-CoA reductase inhibitors (statins)?
Answer: Inhibit the rate-limiting step of hepatic cholesterol synthesis
Statins competitively inhibit HMG-CoA reductase, the enzyme catalyzing the rate-limiting step in cholesterol biosynthesis in the liver.
Which type of drug interaction occurs when one drug alters the absorption of another by chelation?
Answer: Pharmacokinetic interaction
Chelation-based absorption interactions are pharmacokinetic, where drugs like tetracyclines bind divalent cations (Ca2+, Mg2+) forming insoluble complexes that reduce absorption.
The narrow therapeutic index of warfarin means that:
Answer: Small changes in dose can lead to toxicity or therapeutic failure
A narrow therapeutic index means the toxic dose is close to the therapeutic dose, requiring careful monitoring to maintain efficacy without causing bleeding.
Which property of a solid dosage form is described by the angle of repose?
Answer: Powder flowability
The angle of repose measures the maximum angle a powder pile makes with a horizontal surface, indicating powder flowability for tablet and capsule manufacturing.
Anticholinergic drugs produce their effects by blocking which receptor type?
Answer: Muscarinic acetylcholine receptors
Anticholinergic drugs competitively block muscarinic receptors, inhibiting parasympathetic effects such as increased secretions, bradycardia, and smooth muscle contraction.
In the context of clinical pharmacy, what does AUC (Area Under the Curve) represent?
Answer: Total drug exposure over time
AUC represents the total drug exposure to systemic circulation over a defined time period and is directly proportional to the amount of drug absorbed.