ASPS ASPS Wound Healing & Tissue Management 1 — Questions and Answers
Question 1: Which phase of wound healing is characterized by the formation of granulation tissue and angiogenesis?
- Hemostasis
- Inflammatory
- Proliferative (Correct answer)
- Remodeling
Correct answer: Proliferative
The proliferative phase involves fibroblast activity, collagen deposition, and new blood vessel formation (angiogenesis) to build granulation tissue.
Question 2: What is the primary cell type responsible for wound contraction during healing?
- Fibroblast
- Macrophage
- Myofibroblast (Correct answer)
- Neutrophil
Correct answer: Myofibroblast
Myofibroblasts, differentiated from fibroblasts, contain actin filaments that contract to reduce wound size.
Question 3: Which collagen type predominates in mature scar tissue remodeling?
- Type I (Correct answer)
- Type II
- Type III
- Type IV
Correct answer: Type I
Type I collagen, which is stronger and more organized, gradually replaces the Type III collagen deposited during early wound healing.
Question 4: A patient develops a raised, itchy scar that stays within wound borders 6 months post-op. This is best classified as:
- Keloid
- Hypertrophic scar (Correct answer)
- Contracture
- Dehiscence
Correct answer: Hypertrophic scar
Hypertrophic scars are elevated but remain within wound boundaries, unlike keloids which extend beyond the original wound margins.
Question 5: Which growth factor is most critical in initiating the wound healing cascade immediately after injury?
- VEGF
- TGF-β
- PDGF (Correct answer)
- EGF
Correct answer: PDGF
Platelet-derived growth factor (PDGF), released from platelets during hemostasis, is among the first signals that recruit inflammatory cells and initiate healing.
Question 6: What is the recommended management for a superficial partial-thickness burn in a plastic surgery context?
- Immediate split-thickness skin graft
- Moist wound dressings and observation (Correct answer)
- Full-thickness excision
- Hyperbaric oxygen therapy
Correct answer: Moist wound dressings and observation
Superficial partial-thickness burns retain viable dermal appendages and heal well with moist dressings without requiring surgical grafting.
ASPS ASPS Wound Healing & Tissue Management 1
Which phase of wound healing is characterized by the formation of granulation tissue and angiogenesis?