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Immunology and Serology Flashcards

6 cards from real ASCP practice questions. Tap to flip, then mark Knew It or Still Learning — missed cards come back until you master them.

Read the first 6 Immunology and Serology flashcards as text

  1. The VDRL and RPR tests are nontreponemal screening tests for which disease?

    Answer: Syphilis

    VDRL and RPR detect cardiolipin-lecithin antibodies (reagin) produced in response to Treponema pallidum infection.

  2. Which immunoglobulin class is the first produced in a primary immune response?

    Answer: IgM

    IgM is the first antibody class produced during a primary immune response due to its rapid synthesis from B-cell activation.

  3. A positive ANA (antinuclear antibody) test is most associated with which autoimmune disease?

    Answer: Systemic lupus erythematosus (SLE)

    ANA is positive in >95% of SLE patients; anti-dsDNA and anti-Sm are specific confirmatory tests for SLE.

  4. ELISA (enzyme-linked immunosorbent assay) is used as the initial test for HIV diagnosis because:

    Answer: It has high sensitivity to minimize false negatives

    ELISA has high sensitivity for HIV antibody detection, minimizing missed infections; reactive results are confirmed by Western blot or HIV-1/2 differentiation assay.

  5. Rheumatoid factor (RF) is an antibody directed against:

    Answer: The Fc portion of IgG

    Rheumatoid factor is typically an IgM antibody that binds the Fc region of IgG; it is elevated in rheumatoid arthritis and other inflammatory conditions.

  6. Which hepatitis B marker indicates active viral replication and high infectivity?

    Answer: HBeAg

    HBeAg is a secreted antigen associated with active viral replication and correlates with high HBV DNA levels and greater infectivity.