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Immunohematology (Blood Banking) Flashcards

6 cards from real ASCP practice questions. Tap to flip, then mark Knew It or Still Learning — missed cards come back until you master them.

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  1. Cryoprecipitate is the treatment of choice for which specific clotting factor deficiency?

    Answer: Hemophilia A (Factor VIII deficiency)

    Cryoprecipitate is enriched in Factor VIII, fibrinogen, von Willebrand factor, and Factor XIII, making it useful for hemophilia A and hypofibrinogenemia.

  2. Which blood group system is associated with the 'Bombay phenotype' (Oh) lacking the H antigen?

    Answer: H system (FUT1 gene)

    The Bombay phenotype results from homozygous FUT1 mutation, preventing H antigen synthesis; these individuals have anti-H and react with all ABO groups.

  3. Transfusion-related acute lung injury (TRALI) is primarily caused by:

    Answer: Donor anti-HLA or anti-neutrophil antibodies reacting with recipient

    TRALI occurs when donor antibodies (anti-HLA or anti-HNA) activate recipient neutrophils in the lungs within 6 hours of transfusion.

  4. Which RhIG (RhoGAM) dose is given at 28 weeks gestation for Rh prophylaxis?

    Answer: 300 µg (full dose)

    The standard 300-µg dose of Rh immune globulin is given at 28 weeks and again within 72 hours postpartum to prevent Rh sensitization.

  5. Which test detects unexpected antibodies in a patient's serum before transfusion?

    Answer: Antibody screen (indirect antiglobulin test)

    The antibody screen tests patient serum against reagent RBCs with known antigens to detect clinically significant alloantibodies.

  6. The Kleihauer-Betke test is used to:

    Answer: Detect fetal-maternal hemorrhage by quantifying fetal cells in maternal blood

    Acid elution in the Kleihauer-Betke test removes adult hemoglobin, leaving fetal cells staining pink to quantify fetomaternal hemorrhage.