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Hematology Flashcards

6 cards from real ASCP practice questions. Tap to flip, then mark Knew It or Still Learning — missed cards come back until you master them.

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  1. Disseminated intravascular coagulation (DIC) is best characterized by:

    Answer: Prolonged PT/PTT, low fibrinogen, elevated D-dimer

    DIC causes simultaneous clotting and fibrinolysis, resulting in prolonged coagulation times, consumed fibrinogen, and elevated D-dimer.

  2. Which automated hematology parameter best distinguishes iron deficiency anemia from beta-thalassemia minor?

    Answer: RDW and Mentzer Index

    The Mentzer Index (MCV/RBC) 13 suggests iron deficiency, and elevated RDW favors iron deficiency.

  3. The osmotic fragility test is used to diagnose which condition?

    Answer: Hereditary spherocytosis

    Hereditary spherocytosis shows increased osmotic fragility because spherocytes lyse more readily in hypotonic solutions.

  4. Which coagulation factor is tested by the prothrombin time (PT)?

    Answer: Factor VII

    PT measures the extrinsic and common pathways, with Factor VII being the extrinsic pathway factor most sensitive to PT changes.

  5. Auer rods are pathognomonic for which type of leukemia?

    Answer: Acute myeloid leukemia

    Auer rods are fused lysosomes seen only in myeloid blasts, making them diagnostic of acute myeloid leukemia.

  6. Which condition is associated with target cells (codocytes) on peripheral smear?

    Answer: Sickle cell disease and thalassemia

    Target cells are seen in conditions with excess membrane relative to cell content, including thalassemia, sickle cell disease, liver disease, and iron deficiency.