ASCP Hematology 2

Question 1

Sickle cell disease is caused by a substitution of which amino acid in the beta-globin chain?

Accepted Answer

Valine for glutamic acid at position 6

Answer

Lysine for glutamic acid at position 6

Answer

Alanine for glycine at position 6

Answer

Proline for valine at position 6

Question 2

What is the function of the reticuloendothelial system in red blood cell destruction?

Accepted Answer

Removes senescent RBCs via phagocytosis

Answer

Synthesizes new RBCs

Answer

Produces clotting factors

Answer

Regulates platelet production

Question 3

Which finding on a CBC is most indicative of hemolytic anemia?

Accepted Answer

Increased reticulocyte count

Answer

Decreased reticulocyte count

Answer

Decreased MCV

Answer

Increased MCH

Question 4

Which stain is used to identify reticulocytes on a peripheral smear?

Accepted Answer

New methylene blue stain

Answer

Wright-Giemsa stain

Answer

Prussian blue stain

Answer

Periodic acid-Schiff stain

Question 5

A patient has an MCV of 110 fL. Which condition is most likely?

Accepted Answer

Vitamin B12 deficiency

Answer

Iron deficiency anemia

Answer

Thalassemia minor

Answer

Anemia of chronic disease

Question 6

Which leukemia is characterized by the Philadelphia chromosome (BCR-ABL fusion)?

Accepted Answer

Chronic myelogenous leukemia

Answer

Acute lymphoblastic leukemia

Answer

Hairy cell leukemia

Answer

Acute myeloid leukemia