ASCP Clinical Microscopy 2

Question 1

Which urinary crystal is pathognomonic for cystinuria?

Accepted Answer

Flat hexagonal (benzene ring-shaped) crystals

Answer

Coffin-lid (triple phosphate) crystals

Answer

Calcium oxalate crystals

Answer

Uric acid crystals

Question 2

On a peripheral blood smear, target cells (codocytes) are most commonly associated with:

Accepted Answer

Liver disease, thalassemia, hemoglobin C disease, and post-splenectomy

Answer

Iron deficiency anemia

Answer

Vitamin B12 deficiency

Answer

Autoimmune hemolytic anemia

Question 3

Wright-Giemsa stain produces its polychromatic differential staining because it contains:

Accepted Answer

A mixture of acidic (eosin) and basic (methylene blue) dyes that react with acidic and basic cellular components

Answer

Hematoxylin for nuclei only

Answer

Silver stain for reticulin fibers

Answer

Periodic acid-Schiff reagent

Question 4

Hypersegmented neutrophils (5 or more lobes in more than 5% of neutrophils, or any neutrophil with 6 or more lobes) are most characteristic of:

Accepted Answer

Megaloblastic anemia (B12 or folate deficiency)

Answer

Iron deficiency anemia

Answer

Sickle cell disease

Answer

Polycythemia vera

Question 5

Schistocytes on a peripheral blood smear are most consistent with:

Accepted Answer

Microangiopathic hemolytic anemia (MAHA) such as TTP, HUS, or DIC

Answer

Liver disease

Answer

Spherocytosis

Answer

Aplastic anemia

Question 6

In CSF analysis, lymphocytic pleocytosis with elevated protein and normal glucose is most consistent with:

Accepted Answer

Viral (aseptic) meningitis or early tuberculous meningitis

Answer

Bacterial meningitis

Answer

Subarachnoid hemorrhage

Answer

Multiple sclerosis (uncomplicated)