APC Pharmacology Fundamentals 3

Question 1

At steady state, the rate of drug administration equals:

Accepted Answer

The rate of drug elimination

Answer

The rate of absorption

Answer

The volume of distribution divided by half-life

Answer

The peak plasma concentration

Question 2

A drug that exhibits zero-order kinetics is eliminated at a rate that is:

Accepted Answer

Constant regardless of the plasma drug concentration

Answer

Proportional to the plasma drug concentration

Answer

Faster at low concentrations

Answer

Dependent on renal clearance only

Question 3

Which route of administration completely bypasses first-pass hepatic metabolism?

Accepted Answer

Sublingual and intravenous

Answer

Oral

Answer

Sublingual

Answer

Rectal (lower rectum)

Question 4

Tachyphylaxis refers to:

Accepted Answer

Rapid development of tolerance upon repeated administration

Answer

Decreased drug effect after a single large dose

Answer

Increased sensitivity to a drug over time

Answer

Cross-tolerance between unrelated drugs

Question 5

The loading dose of a drug is primarily determined by:

Accepted Answer

Volume of distribution and desired target concentration

Answer

Clearance and desired steady-state concentration

Answer

Bioavailability and half-life

Answer

Protein binding and renal function

Question 6

Which of the following best describes a partial agonist?

Accepted Answer

A drug that produces a submaximal response even when all receptors are occupied

Answer

A drug with high affinity but zero intrinsic efficacy

Answer

A drug that acts at a different receptor subtype than the full agonist

Answer

A drug that requires bioactivation to produce an effect

Question 7

Enterohepatic recycling of a drug typically results in:

Accepted Answer

Prolonged drug action due to reabsorption from the gut

Answer

Faster elimination of the drug

Answer

Increased renal clearance

Answer

Decreased volume of distribution