APC APC Drug Interactions and Contraindications

Question 1

Which combination is a well-known clinically significant drug interaction that can increase the risk of serotonin syndrome?

Accepted Answer

SSRIs and MAOIs

Answer

Amoxicillin and ibuprofen

Answer

Metformin and lisinopril

Answer

Atorvastatin and amlodipine

Question 2

Warfarin's anticoagulant effect is significantly enhanced when co-administered with which of the following?

Accepted Answer

Fluconazole

Answer

Rifampicin

Answer

Cholestyramine

Answer

Carbamazepine

Question 3

Methotrexate toxicity is significantly increased when given concurrently with which drug class?

Accepted Answer

NSAIDs

Answer

Beta-blockers

Answer

Proton pump inhibitors

Answer

Antihistamines

Question 4

Which drug is absolutely contraindicated with sildenafil due to risk of severe hypotension?

Accepted Answer

Organic nitrates

Answer

Atenolol

Answer

Digoxin

Answer

Furosemide

Question 5

In the APC competency framework, identifying drug-drug interactions requires the pharmacist to review which primary resource first?

Accepted Answer

Patient prescription history and current medication list

Answer

The patient's dietary habits

Answer

Insurance formulary listings

Answer

The prescriber's clinical notes only

Question 6

Quinolone antibiotics such as ciprofloxacin should not be administered simultaneously with antacids containing aluminum or magnesium because:

Accepted Answer

They cause chelation reducing quinolone absorption

Answer

They increase quinolone toxicity

Answer

They speed up quinolone metabolism

Answer

They cause nephrotoxicity