AOCNP Advanced Oncology Certified Nurse Practitioner 3 — Questions and Answers
Question 1: Which staging system is used for Hodgkin lymphoma?
- FIGO staging
- Ann Arbor staging with Cotswolds modification (Correct answer)
- TNM staging
- Rai staging
Correct answer: Ann Arbor staging with Cotswolds modification
Hodgkin lymphoma is staged using the Ann Arbor system with Cotswolds modification, which includes designators for symptoms and bulky disease.
Question 2: A patient with NSCLC has a PDL-1 expression of 80% and no driver mutations. What is the preferred first-line treatment?
- Carboplatin/paclitaxel doublet
- Pembrolizumab monotherapy (Correct answer)
- Osimertinib
- Erlotinib
Correct answer: Pembrolizumab monotherapy
Pembrolizumab monotherapy is the preferred first-line treatment for NSCLC with PDL-1 ≥50% and no actionable driver mutations.
Question 3: What is the most common side effect of bevacizumab that requires immediate management?
- Alopecia
- Nausea and vomiting
- Gastrointestinal perforation (Correct answer)
- Peripheral neuropathy
Correct answer: Gastrointestinal perforation
Gastrointestinal perforation is a serious, potentially life-threatening adverse event associated with bevacizumab requiring immediate intervention.
Question 4: A male patient with metastatic castration-resistant prostate cancer has progressed on enzalutamide. BRCA2 mutation is confirmed. What is the next preferred therapy?
- Cabazitaxel
- Olaparib (Correct answer)
- Sipuleucel-T
- Radium-223
Correct answer: Olaparib
Olaparib, a PARP inhibitor, is approved for BRCA-mutated metastatic castration-resistant prostate cancer after progression on enzalutamide or abiraterone.
Question 5: Which paraneoplastic syndrome is most commonly associated with small cell lung cancer?
- Hypercalcemia of malignancy
- Syndrome of inappropriate antidiuretic hormone (SIADH) (Correct answer)
- Polycythemia
- Dermatomyositis
Correct answer: Syndrome of inappropriate antidiuretic hormone (SIADH)
SIADH, caused by ectopic ADH production, is the most common paraneoplastic syndrome associated with small cell lung cancer.
Question 6: What is the recommended screening interval for average-risk adults undergoing colonoscopy for colorectal cancer?
- Every 5 years
- Every 10 years (Correct answer)
- Every 3 years
- Every 15 years
Correct answer: Every 10 years
Average-risk adults should undergo colonoscopy every 10 years starting at age 45 per current guidelines.
Question 7: A patient on long-term corticosteroids for cancer-related inflammation develops a fungal infection. Which opportunistic pathogen is most likely?
- Candida albicans
- Pneumocystis jirovecii (Correct answer)
- Aspergillus fumigatus
- Cryptococcus neoformans
Correct answer: Pneumocystis jirovecii
Pneumocystis jirovecii pneumonia (PCP) is a significant risk in immunosuppressed patients on prolonged corticosteroids and should be prophylaxed against.
AOCNP Advanced Oncology Certified Nurse Practitioner 3
Which staging system is used for Hodgkin lymphoma?