Reading Flashcards
7 cards from real ABD practice questions. Tap to flip, then mark Knew It or Still Learning โ missed cards come back until you master them.
Read the first 7 Reading flashcards as text
A patient presents with a tense subepidermal blister and linear IgG along the basement membrane on direct immunofluorescence. What is the diagnosis?
Answer: Bullous pemphigoid
Bullous pemphigoid shows tense subepidermal bullae with linear IgG and C3 at the dermoepidermal junction.
Which antigens are targeted in bullous pemphigoid?
Answer: BP180 and BP230
Autoantibodies in bullous pemphigoid target hemidesmosomal proteins BP180 and BP230.
Pemphigus vulgaris demonstrates which immunofluorescence pattern?
Answer: Intercellular 'fishnet' IgG
Pemphigus vulgaris shows intercellular 'chicken wire' or fishnet IgG deposition between keratinocytes.
Dermatitis herpetiformis is associated with which systemic condition?
Answer: Celiac disease
Dermatitis herpetiformis is strongly linked to gluten-sensitive enteropathy (celiac disease).
Which drug is first-line for dermatitis herpetiformis symptom control?
Answer: Dapsone
Dapsone rapidly relieves the intense pruritus of dermatitis herpetiformis.
A positive Nikolsky sign indicates:
Answer: Epidermal detachment with lateral pressure
The Nikolsky sign is separation of the epidermis with tangential pressure, seen in pemphigus and TEN.
Before starting dapsone, which laboratory test is essential to prevent hemolysis?
Answer: G6PD level
G6PD deficiency predisposes to dapsone-induced hemolytic anemia, so it must be checked first.