Inflammatory Dermatoses Flashcards

Atopic dermatitis in infancy classically involves which body regions?

Answer: Cheeks and extensor surfaces

Infantile atopic dermatitis favors the face (cheeks) and extensor surfaces, shifting to flexures later in childhood.

A loss-of-function mutation in which gene is a major genetic risk factor for atopic dermatitis?

Answer: Filaggrin (FLG)

Filaggrin mutations impair the epidermal barrier and strongly predispose to atopic dermatitis and ichthyosis vulgaris.

The 'atopic triad' associated with atopic dermatitis includes asthma, allergic rhinitis, and what?

Answer: Atopic dermatitis (eczema) itself

The atopic triad comprises atopic dermatitis, allergic rhinitis, and asthma.

Eczema herpeticum, a dermatologic emergency in atopic patients, is caused by disseminated infection with which virus?

Answer: Herpes simplex virus

Eczema herpeticum is widespread HSV infection over eczematous skin, requiring prompt antiviral therapy.

Which topical calcineurin inhibitor is used as a steroid-sparing agent for atopic dermatitis, especially on the face?

Answer: Tacrolimus

Tacrolimus (and pimecrolimus) are calcineurin inhibitors useful for sensitive areas without steroid atrophy risk.

Dupilumab, approved for moderate-to-severe atopic dermatitis, blocks the shared receptor subunit of which two cytokines?

Answer: IL-4 and IL-13

Dupilumab targets the IL-4 receptor alpha subunit, inhibiting IL-4 and IL-13 signaling central to Th2 inflammation.

Dennie-Morgan folds and hyperlinear palms are physical clues supporting which diagnosis?

Answer: Atopic dermatitis

Dennie-Morgan infraorbital folds and hyperlinear palms are minor stigmata of the atopic constitution.