Dermatopathology Flashcards
7 cards from real ABD practice questions. Tap to flip, then mark Knew It or Still Learning — missed cards come back until you master them.
Read the first 7 Dermatopathology flashcards as text
A biopsy shows acantholysis with a 'row of tombstones' basal cell appearance and intraepidermal, suprabasal clefting. Which disease is this?
Answer: Pemphigus vulgaris
Suprabasal acantholysis leaving a 'row of tombstones' of basal keratinocytes is classic for pemphigus vulgaris.
Direct immunofluorescence showing granular IgA deposits in the dermal papillae supports which diagnosis?
Answer: Dermatitis herpetiformis
Granular IgA in the dermal papillary tips is the hallmark of dermatitis herpetiformis.
A cutaneous tumor shows peripheral palisading of basaloid cells with clefting (retraction) from the surrounding stroma. What is the diagnosis?
Answer: Basal cell carcinoma
Peripheral palisading of basaloid nests with stromal retraction artifact is characteristic of basal cell carcinoma.
Which histologic finding is most characteristic of a Spitz nevus?
Answer: Kamino bodies
Kamino bodies (eosinophilic PAS-positive globules at the junction) are characteristic of a Spitz nevus.
Pautrier microabscesses (intraepidermal collections of atypical lymphocytes) are a diagnostic feature of which condition?
Answer: Mycosis fungoides
Pautrier microabscesses are clusters of atypical T-cells in the epidermis seen in mycosis fungoides (cutaneous T-cell lymphoma).
A Fite (acid-fast) stain would be most useful in diagnosing which cutaneous infection?
Answer: Leprosy (Hansen disease)
The Fite stain is a modified acid-fast stain optimal for demonstrating Mycobacterium leprae.
A dermal spindle-cell tumor stains diffusely positive for S-100 and SOX10 and shows wavy nuclei. Which tumor is most likely?
Answer: Neurofibroma
S-100/SOX10-positive spindle cells with wavy 'comma-shaped' nuclei indicate neural differentiation, as in neurofibroma.