Cutaneous Oncology Flashcards

Muir-Torre syndrome links sebaceous neoplasms with an increased risk of which internal malignancy?

Answer: Colorectal and other Lynch-spectrum cancers

Muir-Torre is a variant of Lynch syndrome with mismatch-repair defects predisposing to colorectal and genitourinary cancers.

Which stain best highlights the eccrine ductal differentiation of microcystic adnexal carcinoma versus a benign syringoma?

Answer: Depth of infiltration and perineural invasion on excision

MAC is distinguished from syringoma largely by its deep infiltrative growth and perineural invasion rather than by a single stain.

The AJCC 8th edition changed melanoma T-staging by adding which factor for T1 tumors?

Answer: Ulceration and a 0.8 mm cutoff defining T1a vs T1b

In AJCC 8, T1b is defined by thickness ≥0.8 mm or ulceration, and mitotic rate was removed as a T-category criterion.

Angiosarcoma of the scalp in elderly patients typically presents as:

Answer: A bruise-like violaceous plaque that enlarges

Cutaneous angiosarcoma often mimics a persistent, enlarging bruise on the scalp or face of older adults.

Which vascular tumor is associated with HHV-8 and immunosuppression?

Answer: Kaposi sarcoma

Kaposi sarcoma is driven by human herpesvirus 8 and is common in immunosuppressed or HIV-positive patients.

For low-risk actinic keratoses, field therapy commonly uses which agent?

Answer: Topical 5-fluorouracil

Topical 5-FU is a standard field-directed treatment for multiple actinic keratoses.

Nicotinamide (vitamin B3) supplementation has been shown to do what in high-risk patients?

Answer: Reduce the rate of new keratinocyte carcinomas and actinic keratoses

Oral nicotinamide reduces incidence of new nonmelanoma skin cancers and actinic keratoses in high-risk patients.