Cutaneous Oncology Flashcards

Mohs micrographic surgery offers its advantage primarily through:

Answer: Complete peripheral and deep margin assessment of 100% of the margin

Mohs evaluates essentially the entire surgical margin, maximizing cure while sparing normal tissue.

Which of the following is an accepted appropriate-use indication for Mohs surgery?

Answer: Recurrent BCC on the nose

Recurrent tumors and high-risk locations like the central face are strong Mohs indications per AUC criteria.

The BRAF V600E mutation, targetable by vemurafenib/dabrafenib, is found in approximately what fraction of cutaneous melanomas?

Answer: About 40-50%

Roughly 40-50% of cutaneous melanomas harbor an activating BRAF mutation, most commonly V600E.

Which melanoma subtype is most commonly associated with KIT mutations?

Answer: Acral and mucosal melanoma

Acral and mucosal melanomas more frequently harbor KIT alterations, guiding imatinib use.

Immune checkpoint inhibitor-induced vitiligo-like depigmentation in a melanoma patient is generally associated with:

Answer: A favorable treatment response

Development of vitiligo-like depigmentation during checkpoint therapy correlates with a better clinical response.

Keratoacanthoma is best regarded histologically as:

Answer: A well-differentiated variant on the SCC spectrum

Keratoacanthoma is considered a well-differentiated form of squamous cell carcinoma despite frequent spontaneous regression.

Which syndrome predisposes to multiple basal cell carcinomas, odontogenic keratocysts, and palmar pits?

Answer: Gorlin (nevoid basal cell carcinoma) syndrome

Gorlin syndrome results from PTCH1 mutations causing numerous BCCs, jaw cysts, and palmar/plantar pits.