Cutaneous Oncology Flashcards
7 cards from real ABD practice questions. Tap to flip, then mark Knew It or Still Learning — missed cards come back until you master them.
Read the first 7 Cutaneous Oncology flashcards as text
Merkel cell carcinoma is most strongly associated with which infectious agent?
Answer: Merkel cell polyomavirus
Merkel cell polyomavirus integration drives the majority of Merkel cell carcinomas.
Which immunostain shows a characteristic paranuclear dot pattern in Merkel cell carcinoma?
Answer: CK20
CK20 typically shows perinuclear dot-like staining while TTF-1 is negative, helping distinguish MCC from metastatic small cell lung cancer.
The first-line systemic therapy class for advanced Merkel cell carcinoma is:
Answer: PD-1/PD-L1 checkpoint inhibitors
Avelumab and pembrolizumab (PD-1/PD-L1 blockade) are first-line for advanced MCC.
Extramammary Paget disease of the vulva most often stains positively for which marker?
Answer: CK7
The intraepidermal adenocarcinoma cells of EMPD are characteristically CK7 positive.
Which finding on a mycosis fungoides biopsy is most specific for the diagnosis?
Answer: Pautrier microabscesses
Pautrier microabscesses—intraepidermal collections of atypical lymphocytes—are highly specific for mycosis fungoides.
Sézary syndrome is defined by mycosis fungoides plus which additional feature?
Answer: Erythroderma with circulating atypical T-cells
Sézary syndrome is the leukemic variant of CTCL with erythroderma and clonal Sézary cells in blood.
Atypical fibroxanthoma classically arises in which clinical setting?
Answer: Sun-damaged head and neck of elderly patients
AFX typically presents as a rapidly growing nodule on chronically sun-damaged skin of the head and neck in the elderly.