Regulations and Compliance Flashcards

What is the purpose of IACUC protocol review before research begins?

Answer: To evaluate scientific merit, welfare considerations, and regulatory compliance before animal use

Protocol review evaluates justification, species and numbers, pain minimization, alternatives, anesthesia plans, humane endpoints, and personnel qualifications.

What is an Occupational Health and Safety Program in an animal facility?

Answer: A comprehensive program to identify, assess, and mitigate workplace hazards for personnel

An OHSP addresses workplace hazards including allergens, zoonoses, physical injuries, and chemical exposures through risk assessment, training, PPE, and medical monitoring.

What is the Institutional Official's role?

Answer: Bearing institutional responsibility, signing regulatory assurances, and ensuring adequate resources

The IO is the senior administrator who bears institutional responsibility, signs the PHS Assurance, and ensures adequate resources for the program.

What training is required for personnel who handle laboratory animals?

Answer: Species-specific training in handling, care, reporting, and regulations

All personnel must receive training appropriate to their responsibilities including handling, husbandry, pain recognition, reporting, and regulations.

What is the significance of the PHS Policy on Humane Care and Use of Laboratory Animals?

Answer: It establishes requirements for PHS-funded institutions, extending protections to all vertebrate animals

PHS Policy applies to all PHS-funded institutions and requires compliance with the Guide for all vertebrate animal research, covering species excluded from AWA.

What should an ALAT do if they witness an unapproved procedure on an animal?

Answer: Report the concern to the veterinarian, IACUC, or through institutional reporting mechanisms

An ALAT has a responsibility and legal protection to report concerns through proper channels. Whistleblower protections prevent retaliation.