Anesthesia and Analgesia in Laboratory Animals Flashcards
7 cards from real ALAT practice questions. Tap to flip, then mark Knew It or Still Learning — missed cards come back until you master them.
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Which of the following best describes 'balanced anesthesia' in laboratory animal medicine?
Answer: Combining multiple agents to achieve analgesia, muscle relaxation, and unconsciousness
Balanced anesthesia uses multiple drugs targeting different pathways to reduce individual drug doses and side effects.
An IACUC protocol requires refinement of anesthetic procedures. Which of the following changes would be considered a refinement?
Answer: Replacing injectable anesthesia with inhalant anesthesia for shorter procedures
Switching to inhalant anesthesia for short procedures allows rapid recovery and titration, improving animal welfare.
Which drug is commonly used to reverse the sedative and cardiovascular effects of xylazine in laboratory animals?
Answer: Atipamezole
Atipamezole is a selective alpha-2 adrenoceptor antagonist that effectively reverses xylazine's effects.
A guinea pig undergoing surgery under ketamine/xylazine anesthesia begins showing signs of a light anesthetic plane. Which of the following is the SAFEST supplemental agent to administer?
Answer: Isoflurane via mask at 1–2%
Supplementing injectable anesthesia with low-concentration isoflurane allows titrated depth control with rapid adjustment.
Which of the following best describes the purpose of a pre-anesthetic fast in laboratory rabbits?
Answer: To reduce intestinal gas and improve respiration
Rabbits cannot vomit, so fasting is done to reduce GI gas that can impair diaphragm movement and ventilation, not to prevent aspiration.
Which route of analgesic administration is most appropriate for a mouse that is difficult to restrain for injections post-surgery?
Answer: Oral administration via drinking water or gel
Oral analgesics delivered in drinking water or gel formulations reduce handling stress and are practical for small rodents post-surgery.
What is the primary reason that intraperitoneal (IP) injection is commonly used for anesthetic drug delivery in mice and rats?
Answer: It is easy to perform and allows administration of larger volumes
IP injection is technically simple and accommodates larger drug volumes than IM or IV routes in small rodents.