ALAT Species-Specific Care and Experimental Models Questions and Answers Flashcards
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Read the first 7 ALAT Species-Specific Care and Experimental Models Questions and Answers flashcards as text
Ferrets are commonly used as an animal model for which human infectious disease because they share similar receptor distribution in the respiratory tract?
Answer: Influenza
Ferrets have sialic acid receptors in the respiratory tract similar to humans, making them an excellent model for influenza virus infection and transmission studies.
Which of the following statements about Mongolian gerbils used as laboratory animals is correct?
Answer: They are prone to spontaneous epileptiform seizures
Approximately 20-40% of Mongolian gerbils develop spontaneous epileptiform seizures, making them a naturally occurring model for epilepsy research.
A non-human primate (NHP) is observed self-mutilating and showing stereotypic behaviors. The most appropriate first response is to:
Answer: Notify the veterinary staff and implement environmental enrichment strategies
Self-mutilation and stereotypies in NHPs typically indicate psychological distress; the veterinary team should be notified and environmental enrichment implemented immediately.
The Sprague-Dawley rat is most accurately described as:
Answer: An outbred stock commonly used in toxicology and pharmacology studies
Sprague-Dawley is an outbred stock of rat, characterized by genetic diversity, and is widely used in general biomedical, toxicology, and pharmacology research.
Which of the following correctly describes why guinea pigs require dietary vitamin C supplementation?
Answer: Guinea pigs lack the enzyme L-gulonolactone oxidase needed to synthesize vitamin C
Guinea pigs, like humans and some primates, lack L-gulonolactone oxidase and therefore cannot synthesize vitamin C endogenously, requiring dietary supplementation.
A minipig model is selected for a dermal toxicology study. What characteristic makes swine skin particularly relevant for this type of research?
Answer: Swine skin is anatomically and physiologically similar to human skin in thickness and composition
Pig skin closely resembles human skin in epidermal thickness, dermal composition, and permeability, making it an excellent model for dermal absorption and toxicology studies.
When working with zebrafish (Danio rerio) embryos used in developmental toxicology studies, which of the following is a key advantage of this model?
Answer: Zebrafish embryos are transparent, allowing direct visualization of organ development
Zebrafish embryos are optically transparent, enabling real-time visualization of organ development, cardiac function, and toxicological effects without invasive procedures.