ALAT ALAT Species-Specific Care and Experimental Models Questions and Answers 2

Question 1

What is the term for mice that are raised in a completely sterile environment and have no microbial colonization?

Accepted Answer

Germ-free (axenic) mice

Answer

SPF (specific pathogen free) mice

Answer

Inbred mice

Answer

Transgenic mice

Question 2

Which zoonotic disease risk is most associated with non-human primates (NHPs) in US research facilities?

Accepted Answer

Herpes B virus (Macacine alphaherpesvirus 1)

Answer

Rabies

Answer

Hantavirus

Answer

Ringworm (dermatophytosis)

Question 3

What is the purpose of sentinel animals in a laboratory animal colony?

Accepted Answer

To detect the presence of pathogens in the colony through health monitoring

Answer

To guard the facility against unauthorized entry

Answer

To serve as the first animals used in new experimental protocols

Answer

To train new staff on handling techniques

Question 4

What does 'SPF' stand for in the context of laboratory animal health status?

Accepted Answer

Specific Pathogen Free

Answer

Standard Protocol Foundation

Answer

Sterile Pathogen Free

Answer

Specialized Production Facility

Question 5

Which of the following is a normal physiological feature of rats that differentiates them from mice in a research setting?

Accepted Answer

Rats cannot vomit due to their anatomy

Answer

Rats do not have a gallbladder

Answer

Rats have a bicameral heart

Answer

Rats are obligate carnivores

Question 6

When housing zebrafish (Danio rerio) in a research facility, which water quality parameter is most critical to monitor?

Accepted Answer

pH, temperature, conductivity, and ammonia levels

Answer

Water hardness only

Answer

Dissolved oxygen and salinity only

Answer

Water color and turbidity only