Adult-Gerontology CNS Test Pharmacology and Therapeutics

Question 1

Which class of medications is considered potentially inappropriate for older adults per the Beers Criteria due to anticholinergic effects?

Accepted Answer

First-generation antihistamines

Answer

ACE inhibitors

Answer

Beta-blockers

Answer

Statins

Question 2

Which pharmacokinetic change in older adults most significantly affects first-pass drug metabolism?

Accepted Answer

Decreased hepatic blood flow

Answer

Increased total body water

Answer

Increased lean body mass

Answer

Increased albumin levels

Question 3

Which medication requires the most careful dosing adjustment in an older adult with a GFR of 35 mL/min?

Accepted Answer

Metformin

Answer

Lisinopril

Answer

Amlodipine

Answer

Atorvastatin

Question 4

A CNS is reconciling medications for an 80-year-old. Which drug-drug interaction is most clinically significant?

Accepted Answer

Warfarin + aspirin

Answer

Metoprolol + amlodipine

Answer

Lisinopril + amlodipine

Answer

Metformin + sitagliptin

Question 5

Which opioid is listed as potentially inappropriate for older adults per the Beers Criteria due to neurotoxic metabolite accumulation?

Accepted Answer

Meperidine

Answer

Morphine

Answer

Oxycodone

Answer

Hydromorphone

Question 6

What is the recommended first-line pharmacological treatment for osteoporosis in postmenopausal women?

Accepted Answer

Bisphosphonates

Answer

Calcium supplementation alone

Answer

Selective estrogen receptor modulators

Answer

Calcitonin