ADM Neurobiology of Addiction

Question 1

Which neurotransmitter system is primarily responsible for the rewarding effects of most addictive substances?

Accepted Answer

Dopaminergic system

Answer

Serotonergic system

Answer

Cholinergic system

Answer

Histaminergic system

Question 2

The mesolimbic dopamine pathway originates from which brain region?

Accepted Answer

Ventral tegmental area

Answer

Locus coeruleus

Answer

Raphe nuclei

Answer

Substantia nigra pars compacta

Question 3

Long-term substance use causes downregulation of dopamine D2 receptors, contributing primarily to which phenomenon?

Accepted Answer

Tolerance and anhedonia

Answer

Sensitization

Answer

Hyperalgesia

Answer

Kindling

Question 4

Which brain structure is most implicated in conditioned cue-induced drug craving?

Accepted Answer

Amygdala

Answer

Hippocampus

Answer

Cerebellum

Answer

Thalamus

Question 5

Dysfunction of the prefrontal cortex in addiction primarily impairs which capacity?

Accepted Answer

Inhibitory control and decision-making

Answer

Sensory perception

Answer

Motor coordination

Answer

Declarative memory formation

Question 6

Opioid-induced euphoria and analgesia are primarily mediated by agonism at which receptor type?

Accepted Answer

Mu-opioid receptors

Answer

NMDA receptors

Answer

Kappa-opioid receptors

Answer

GABA-B receptors

Question 7

Neurobiological tolerance to opioids is primarily driven by which cellular mechanism?

Accepted Answer

Receptor desensitization and internalization

Answer

Receptor upregulation and sensitization

Answer

Increased neurotransmitter synthesis

Answer

Enhanced blood-brain barrier permeability