ABPS ABPS Pharmacology & Therapeutics

Question 1

Which class of medications is contraindicated in patients with a known hypersensitivity to sulfonamides due to cross-reactivity concerns?

Accepted Answer

Thiazide diuretics

Answer

Beta-blockers

Answer

ACE inhibitors

Answer

Calcium channel blockers

Question 2

A patient on warfarin begins taking rifampin for tuberculosis. What change in INR would you expect?

Accepted Answer

Decreased INR due to enzyme induction

Answer

Increased INR due to enzyme inhibition

Answer

No change in INR

Answer

Unpredictable fluctuations only

Question 3

Which opioid analgesic is considered safest for use in patients with severe renal impairment?

Accepted Answer

Fentanyl

Answer

Morphine

Answer

Codeine

Answer

Meperidine

Question 4

A physician prescribes metformin for a newly diagnosed type 2 diabetic. Which condition is an absolute contraindication to metformin use?

Accepted Answer

eGFR < 30 mL/min/1.73m²

Answer

Mild hypertension

Answer

Obesity

Answer

Hypothyroidism

Question 5

Which beta-blocker is cardioselective and preferred in patients with mild asthma who require beta-blocker therapy?

Accepted Answer

Metoprolol

Answer

Propranolol

Answer

Carvedilol

Answer

Labetalol

Question 6

A patient taking an SSRI is started on tramadol for pain. What serious drug interaction should the prescriber monitor for?

Accepted Answer

Serotonin syndrome

Answer

Hypertensive crisis

Answer

Neuroleptic malignant syndrome

Answer

Anticholinergic toxidrome