ABP Oral Pathology and Mucosal Diseases

Question 1

Which medication class is most commonly associated with drug-induced gingival enlargement along with phenytoin and cyclosporine?

Accepted Answer

Calcium channel blockers such as nifedipine

Answer

Anticonvulsants (phenytoin), immunosuppressants (cyclosporine) and calcium channel blockers (nifedipine, amlodipine) are the classic causes. Plaque control reduces severity.

Question 2

Which histologic and immunofluorescence finding is characteristic of mucous membrane pemphigoid?

Accepted Answer

Subepithelial separation with linear IgG/C3 at the basement membrane zone

Answer

Mucous membrane pemphigoid is a subepithelial blistering disease with linear deposition of IgG and/or C3 along the basement membrane. It commonly presents as desquamative gingivitis.

Question 3

A positive Nikolsky sign with intraepithelial acantholysis is most characteristic of which disease?

Accepted Answer

Pemphigus vulgaris

Answer

Pemphigus vulgaris involves autoantibodies against desmogleins, causing loss of keratinocyte adhesion (acantholysis). A Tzanck smear shows acantholytic cells.

Question 4

Which clinical finding is most classic for oral lichen planus?

Accepted Answer

Wickham striae

Answer

Wickham striae are lacy white reticular lines, most often on the buccal mucosa. Biopsy shows a band-like lymphocytic infiltrate and sawtooth rete ridges.

Question 5

Which oral lesion carries the highest risk of malignant transformation?

Accepted Answer

Erythroplakia

Answer

Erythroplakia has the highest malignant potential, and most lesions show dysplasia or carcinoma in situ at biopsy. Leukoplakia has a lower but real risk, and a persistent lesion needs biopsy.

(ABP) American Board of Periodontology Practice Test

(ABP) American Board of Periodontology Practice Test

ABP Oral Pathology and Mucosal Diseases