Regenerative Techniques Flashcards

Which furcation classification system uses the terms 'F1,' 'F2,' and 'F3' with superscripts to denote both horizontal and vertical involvement?

Answer: Tarnow and Fletcher classification

Tarnow and Fletcher's system adds vertical subclassifications (A, B, C based on distance from the CEJ to the furcation roof) to horizontal classes, allowing more precise prognostication for regenerative therapy.

When combining EMD with a bone substitute graft for an intrabony defect, the MOST important clinical rationale is to:

Answer: Use the graft as a scaffold to prevent membrane collapse

Adding a bone substitute graft to EMD provides structural support to prevent soft tissue collapse into the defect, maintaining the space necessary for regeneration in wide or complex defects.

Systemic conditions that are ABSOLUTE contraindications to regenerative periodontal surgery include:

Answer: Patients on bisphosphonate therapy with history of MRONJ

A history of medication-related osteonecrosis of the jaw (MRONJ) associated with bisphosphonate therapy is an absolute contraindication because surgical trauma may trigger new or recurrent osteonecrosis.

In a randomized controlled trial comparing GTR to open flap debridement (OFD), which outcome measure would provide the STRONGEST evidence of true periodontal regeneration?

Answer: Histologic evidence of new cementum, PDL, and bone on extracted teeth

Histologic evaluation of extracted teeth remains the gold standard for confirming true regeneration, as it directly demonstrates new cementum, inserting PDL fibers, and alveolar bone — outcomes not visible on X-ray or clinical probing.

Which factor is MOST consistently associated with reduced regenerative outcomes following GTR surgery in multiple systematic reviews?

Answer: Cigarette smoking

Cigarette smoking consistently reduces regenerative outcomes in GTR surgery across multiple systematic reviews, with smokers showing significantly less bone fill and CAL gain than non-smokers.

A demineralized freeze-dried bone allograft (DFDBA) is considered osteoinductive primarily because the demineralization process:

Answer: Exposes bone morphogenetic proteins (BMPs) embedded in the bone matrix

Demineralization of FDBA exposes bone morphogenetic proteins and other growth factors that were previously bound within the mineral matrix, giving DFDBA its osteoinductive capability.

Which post-operative instruction is MOST critical to the success of a regenerative procedure in the first 6 weeks after surgery?

Answer: Complete avoidance of mechanical plaque removal at the surgical site

Complete avoidance of mechanical disruption at the surgical site for 6 weeks is critical because physical disturbance of the fibrin clot or membrane during the healing phase can collapse the regenerative space and cause failure.