Regenerative Techniques Flashcards
7 cards from real ABP practice questions. Tap to flip, then mark Knew It or Still Learning — missed cards come back until you master them.
Read the first 7 Regenerative Techniques flashcards as text
In the 'wound healing' model of periodontal regeneration, which event must occur FIRST for successful regeneration?
Answer: Vascular ingrowth into the clot
Vascular ingrowth into the fibrin clot is the first critical event in wound healing, providing oxygen and nutrients necessary for subsequent cell migration and proliferation.
Platelet-rich fibrin (PRF) differs from PRP primarily because PRF:
Answer: Does not require addition of thrombin or calcium chloride to activate
PRF is a second-generation platelet concentrate that polymerizes naturally without the addition of exogenous thrombin or calcium chloride, forming a fibrin matrix through the body's own coagulation cascade.
A 45-year-old patient presents with a 9mm probing depth and 6mm radiographic bone loss at the mesial of #19. Radiographically, the defect appears as a narrow angular defect. Which treatment would MOST likely yield the best regenerative outcome?
Answer: GTR with a barrier membrane ± bone graft
Deep, narrow intrabony defects with angular morphology respond best to GTR with or without bone graft, as these defects have favorable geometry for space maintenance and cell repopulation.
Which term describes the property of a graft material that actively induces new bone formation by stimulating host cells to differentiate into osteoblasts?
Answer: Osteoinductive
Osteoinduction refers to the ability of a material to stimulate host mesenchymal cells to differentiate into bone-forming cells (osteoblasts), typically through growth factors like BMPs.
The 'biological width' concept is relevant to regenerative therapy because violation of it can lead to:
Answer: Chronic osseous defect and bone loss around the restoration margin
Violation of biological width by restorative margins triggers a chronic inflammatory response that results in bone resorption as the periodontium attempts to re-establish the 2mm of supracrestal attachment.
Which suturing technique is BEST for achieving primary closure over a GTR membrane placed in an anterior interdental site?
Answer: Vertical mattress sutures
Vertical mattress sutures provide eversion of the wound edges, reduce dead space, and achieve tension-free primary closure of papillary flaps — critical for preventing membrane exposure.
The 'inside-out' model of regeneration in GTR proposes that PDL cells repopulate the root surface from which direction?
Answer: From the apical PDL upward along the root
The inside-out model proposes that PDL progenitor cells migrate coronally from the apical intact PDL to repopulate the exposed root surface when epithelium and gingival cells are excluded by the membrane.