ABP ABP Pharmacology and Antimicrobials 1

Question 1

Which systemic antibiotic combination is most commonly used as an adjunct to scaling and root planing for aggressive periodontitis?

Accepted Answer

Amoxicillin + metronidazole

Answer

Amoxicillin combined with metronidazole targets both Aggregatibacter actinomycetemcomitans and anaerobic pathogens associated with aggressive periodontitis.

Question 2

What is the mechanism of action of subantimicrobial-dose doxycycline (SDD) when used as a periodontal adjunct?

Accepted Answer

Matrix metalloproteinase inhibition

Answer

SDD at 20 mg twice daily inhibits host-derived matrix metalloproteinases, reducing collagen breakdown without exerting antibiotic effects.

Question 3

Which locally delivered antimicrobial agent releases doxycycline hyclate directly into the periodontal pocket?

Accepted Answer

Atridox (doxycycline hyclate 10%)

Answer

Atridox is a biodegradable subgingival gel containing 10% doxycycline hyclate that provides sustained release within the periodontal pocket.

Question 4

For a patient allergic to penicillin requiring prophylactic antibiotic coverage before periodontal surgery, which agent is the preferred alternative?

Accepted Answer

Clindamycin 600 mg

Answer

Clindamycin 600 mg orally one hour before the procedure is the standard AHA-recommended alternative for penicillin-allergic patients requiring prophylaxis.

Question 5

Chlorhexidine gluconate oral rinse at 0.12% is considered most effective when used in which clinical scenario?

Accepted Answer

Post-surgical infection prevention and plaque suppression

Answer

Chlorhexidine 0.12% rinse is best used short-term post-surgically to suppress plaque and reduce infection risk when mechanical hygiene is difficult.

(ABP) American Board of Periodontology Practice Test

(ABP) American Board of Periodontology Practice Test

ABP ABP Pharmacology and Antimicrobials 1