Uveitis Flashcards

A young myopic woman has acute unilateral photopsia after a flu-like illness, with small gray-white outer retinal dots and foveal granularity that resolve over weeks. What is the diagnosis?

Answer: Multiple evanescent white dot syndrome

MEWDS is a self-limited, usually unilateral white dot syndrome in young myopic women, often with a viral prodrome.

On fluorescein angiography, APMPPE lesions characteristically show which pattern?

Answer: Early hypofluorescence (blockage) with late staining

Placoid lesions of APMPPE block early and stain late, reflecting choriocapillaris hypoperfusion.

Patients with pars planitis should be evaluated for which associated systemic disease, particularly before starting anti-TNF therapy?

Answer: Multiple sclerosis

Intermediate uveitis is associated with MS, and anti-TNF agents can worsen demyelinating disease.

What is the most common cause of vision loss in intermediate uveitis?

Answer: Cystoid macular edema

Cystoid macular edema is the leading cause of decreased vision in intermediate uveitis.

Which finding helps distinguish presumed ocular histoplasmosis syndrome from multifocal choroiditis?

Answer: Absence of vitreous or anterior chamber inflammation

POHS characteristically lacks intraocular inflammation, whereas multifocal choroiditis shows vitritis.

An elderly patient has bilateral vitritis that responds poorly to corticosteroids and creamy subretinal pigment epithelial infiltrates. Which vitreous finding most supports the likely diagnosis?

Answer: IL-10 to IL-6 ratio greater than 1

Primary vitreoretinal lymphoma, usually diffuse large B-cell, produces high IL-10 relative to IL-6.

Which is the most common vision-threatening complication of punctate inner choroidopathy?

Answer: Choroidal neovascularization

PIC lesions in young myopic women frequently develop choroidal neovascularization.