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Uveitis Flashcards

7 cards from real ABO practice questions. Tap to flip, then mark Knew It or Still Learning — missed cards come back until you master them.

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  1. Multiple cream-colored ovoid choroidal lesions radiating from the optic disc with vitritis in a middle-aged White patient are most strongly associated with which HLA allele?

    Answer: HLA-A29

    Birdshot chorioretinopathy has one of the strongest known HLA associations, with HLA-A29.

  2. A fluffy white focus of retinochoroiditis adjacent to a pigmented scar with dense overlying vitritis ('headlight in the fog') is most consistent with which diagnosis?

    Answer: Ocular toxoplasmosis

    Reactivated Toxoplasma retinochoroiditis typically appears at the border of an old pigmented scar with dense vitritis.

  3. Which feature best distinguishes Vogt-Koyanagi-Harada disease from sympathetic ophthalmia?

    Answer: Absence of a history of penetrating ocular trauma or surgery

    Both diseases share similar clinical and histologic findings, but VKH requires no prior penetrating injury or intraocular surgery.

  4. To minimize the risk of sympathetic ophthalmia, enucleation of a blind, severely injured eye should ideally be performed within what time frame after injury?

    Answer: 2 weeks

    Enucleation within about 2 weeks of injury is believed to reduce the risk of sympathetic ophthalmia.

  5. An immunocompetent patient has rapidly progressive circumferential peripheral retinal necrosis, occlusive arteritis, and marked vitritis. What is the most appropriate initial treatment?

    Answer: Intravenous acyclovir or high-dose oral valacyclovir

    Acute retinal necrosis is caused by VZV or HSV and requires prompt systemic antiviral therapy, often with intravitreal antivirals.

  6. Below which CD4 count does the risk of CMV retinitis rise sharply in patients with AIDS?

    Answer: 50 cells/µL

    CMV retinitis typically occurs when CD4 counts fall below 50 cells/µL.

  7. Before starting immunosuppression for a patient with serpiginous-like choroiditis from an endemic region, which test is most important?

    Answer: Interferon-gamma release assay for tuberculosis

    Tuberculous serpiginous-like choroiditis mimics serpiginous choroiditis and worsens with immunosuppression alone.