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Ocular Oncology Flashcards

7 cards from real ABO practice questions. Tap to flip, then mark Knew It or Still Learning — missed cards come back until you master them.

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  1. Which chromosomal abnormality in uveal melanoma is most strongly associated with metastatic risk?

    Answer: Monosomy 3

    Monosomy 3 (loss of one copy of chromosome 3) is the single most significant prognostic cytogenetic marker in uveal melanoma, strongly associated with high metastatic risk.

  2. Primary intraocular lymphoma (PIOL) most commonly involves which ocular structures?

    Answer: Vitreous and subretinal space

    PIOL is typically a diffuse large B-cell lymphoma that most commonly involves the vitreous and subretinal space, often associated with CNS lymphoma.

  3. What is the hallmark CT finding of retinoblastoma in children?

    Answer: Calcification within the intraocular mass

    Calcification within the intraocular tumor is the hallmark CT finding of retinoblastoma, present in approximately 90-95% of cases and helpful in distinguishing it from other leukocoric conditions.

  4. Conjunctival melanoma most frequently arises from which precursor lesion?

    Answer: Primary acquired melanosis (PAM) with atypia

    Conjunctival melanoma most commonly (75%) arises from primary acquired melanosis with atypia, which carries a significant risk of malignant transformation proportional to the degree of cytologic atypia.

  5. What is the most common orbital malignancy in adults?

    Answer: Lymphoma

    Lymphoma is the most common orbital malignancy in adults, typically presenting as a painless salmon-colored subconjunctival or orbital mass in older patients.

  6. Which funduscopic feature best distinguishes choroidal melanoma from choroidal metastasis?

    Answer: Orange lipofuscin pigment overlying the tumor

    Orange lipofuscin pigment (lipofuscin deposits on the tumor surface seen by fluorescein angiography) is a classic feature of choroidal melanoma and is rarely seen overlying choroidal metastases.

  7. Orbital rhabdomyosarcoma in children most commonly presents at which age range?

    Answer: 5-10 years

    Orbital rhabdomyosarcoma most commonly presents in children between ages 5-10 years (median age 7-8) with rapidly progressive unilateral proptosis.