ABFAS Pharmacology Fundamentals 2

Question 1

Which opioid analgesic has the highest oral bioavailability and is commonly used for moderate postoperative foot pain?

Accepted Answer

Oxycodone

Answer

Oxycodone has approximately 60-87% oral bioavailability, making it more reliably absorbed than morphine when given orally.

Question 2

A patient on warfarin requires a short course of NSAIDs for postoperative pain. Which NSAID poses the least interaction risk?

Accepted Answer

Celecoxib

Answer

Celecoxib (a selective COX-2 inhibitor) minimally affects platelet aggregation and has a lower risk of clinically significant INR elevation compared to non-selective NSAIDs.

Question 3

What is the primary mechanism by which aminoglycosides cause nephrotoxicity?

Accepted Answer

Accumulation in proximal tubular cells causing oxidative damage

Answer

Aminoglycosides accumulate in proximal tubular cells via megalin-mediated endocytosis, generating reactive oxygen species that cause tubular cell necrosis.

Question 4

Which local anesthetic has the longest duration of action and is most appropriate for postoperative nerve blocks in foot surgery?

Accepted Answer

Bupivacaine

Answer

Bupivacaine provides 8-12+ hours of analgesia due to its high lipid solubility and protein binding, making it ideal for postoperative nerve blocks.

Question 5

A diabetic patient develops a foot infection with Staphylococcus aureus resistant to methicillin (MRSA). Which antibiotic is the first-line oral option?

Accepted Answer

Trimethoprim-sulfamethoxazole

Answer

TMP-SMX (Bactrim) is a first-line oral agent for community-acquired MRSA soft tissue infections when susceptibility is confirmed.

(ABFAS) American Board of Foot and Ankle Surgery Practice Test

(ABFAS) American Board of Foot and Ankle Surgery Practice Test

ABFAS Pharmacology Fundamentals 2