ABD Reading 3

Question 1

A patient presents with a tense subepidermal blister and linear IgG along the basement membrane on direct immunofluorescence. What is the diagnosis?

Accepted Answer

Bullous pemphigoid

Answer

Bullous pemphigoid shows tense subepidermal bullae with linear IgG and C3 at the dermoepidermal junction.

Question 2

Which antigens are targeted in bullous pemphigoid?

Accepted Answer

BP180 and BP230

Answer

Autoantibodies in bullous pemphigoid target hemidesmosomal proteins BP180 and BP230.

Question 3

Pemphigus vulgaris demonstrates which immunofluorescence pattern?

Accepted Answer

Intercellular 'fishnet' IgG

Answer

Pemphigus vulgaris shows intercellular 'chicken wire' or fishnet IgG deposition between keratinocytes.

Question 4

Dermatitis herpetiformis is associated with which systemic condition?

Accepted Answer

Celiac disease

Answer

Dermatitis herpetiformis is strongly linked to gluten-sensitive enteropathy (celiac disease).

Question 5

Which drug is first-line for dermatitis herpetiformis symptom control?

Accepted Answer

Dapsone

Answer

Dapsone rapidly relieves the intense pruritus of dermatitis herpetiformis.

American Board of Dermatology (ABD) Practice Test