ABD Cutaneous Oncology 2

Question 1

Which histologic subtype of basal cell carcinoma carries the highest risk of subclinical extension and local recurrence?

Accepted Answer

Infiltrative/morpheaform

Answer

Nodular

Answer

Superficial

Answer

Pigmented

Question 2

A 62-year-old man has a 2.5 cm squamous cell carcinoma on the ear with perineural invasion. Which feature most upgrades his risk?

Accepted Answer

All contribute but PNI of large nerves is key high-risk

Answer

Tumor location on the ear

Answer

Perineural invasion of a nerve ≥0.1 mm

Answer

Size over 2 cm

Question 3

The Breslow depth is measured from which anatomic landmark?

Accepted Answer

Top of the granular layer to deepest tumor cell

Answer

Basement membrane to deepest tumor cell

Answer

Stratum corneum to base of tumor

Answer

Dermal-subcutaneous junction upward

Question 4

Which immunostain is most useful to confirm melanocytic differentiation in a spindle-cell (desmoplastic) melanoma?

Accepted Answer

S100

Answer

HMB-45

Answer

Melan-A

Answer

Cytokeratin AE1/AE3

Question 5

For melanoma, sentinel lymph node biopsy is generally recommended starting at what Breslow thickness (with no other high-risk features)?

Accepted Answer

0.8 mm

Answer

0.5 mm

Answer

1.0 mm

Answer

2.0 mm

Question 6

A hedgehog pathway inhibitor such as vismodegib is FDA-approved for which malignancy?

Accepted Answer

Locally advanced or metastatic basal cell carcinoma

Answer

Metastatic melanoma

Answer

Cutaneous T-cell lymphoma

Answer

Merkel cell carcinoma

Question 7

Which recurrent gene fusion is characteristic of dermatofibrosarcoma protuberans?

Accepted Answer

COL1A1-PDGFB

Answer

EWSR1-FLI1

Answer

PAX3-FOXO1

Answer

BRAF-KIAA1549