ABD Basic Science and Immunology 2

Question 1

Which cytokine is the principal driver of the Th2 immune axis implicated in atopic dermatitis?

Accepted Answer

IL-4

Answer

IFN-gamma

Answer

IL-17

Answer

TNF-alpha

Question 2

A loss-of-function mutation in the FLG gene predisposes to atopic dermatitis by impairing production of which protein?

Accepted Answer

Filaggrin

Answer

Desmoglein 3

Answer

Collagen VII

Answer

Loricrin

Question 3

Langerhans cells in the epidermis are best characterized by the presence of which cytoplasmic organelle?

Accepted Answer

Birbeck granule

Answer

Weibel-Palade body

Answer

Melanosome

Answer

Odland body

Question 4

Which immunoglobulin class is deposited in the dermal papillae in dermatitis herpetiformis?

Accepted Answer

IgA

Answer

IgG

Answer

IgM

Answer

IgE

Question 5

The type III hypersensitivity reaction responsible for cutaneous leukocytoclastic vasculitis is mediated primarily by:

Accepted Answer

Immune complex deposition

Answer

IgE-mediated mast cell degranulation

Answer

Cytotoxic T cells

Answer

Delayed T-cell response

Question 6

Which structural protein is the target autoantigen in bullous pemphigoid?

Accepted Answer

BP180 (collagen XVII)

Answer

Desmoglein 1

Answer

Desmoglein 3

Answer

Plectin

Question 7

The Th17 pathway, central to psoriasis, is driven by which key cytokine that is the target of secukinumab?

Accepted Answer

IL-17A

Answer

IL-4

Answer

IL-10

Answer

IL-5