ABD ABD Hair and Nail Disorders 2

Question 1

Which FDA-approved oral JAK inhibitor was first approved specifically for severe alopecia areata in adults?

Accepted Answer

Baricitinib

Answer

Baricitinib (Olumiant) received FDA approval in June 2022 as the first systemic treatment specifically indicated for severe alopecia areata in adults.

Question 2

Lichen planopilaris, a scarring alopecia, characteristically shows which dermoscopic finding?

Accepted Answer

Perifollicular scaling and fibrotic white dots

Answer

Lichen planopilaris shows perifollicular scaling, loss of follicular openings, and fibrotic white dots (stellate scarring) on dermoscopy.

Question 3

Terry's nails (proximal white nail with distal pink band) are most commonly associated with which systemic condition?

Accepted Answer

Liver cirrhosis

Answer

Terry's nails, featuring proximal white discoloration with a 0.5-3mm distal pink or red band, are most commonly associated with liver cirrhosis.

Question 4

Hailey-Hailey disease (benign familial pemphigus) is caused by mutations in which gene?

Accepted Answer

ATP2C1 (hSPCA1)

Answer

Hailey-Hailey disease is caused by loss-of-function mutations in ATP2C1 encoding hSPCA1, a Golgi calcium/manganese ATPase pump.

Question 5

Which beta-blocker class medication is a well-established pharmacologic cause of telogen effluvium?

Accepted Answer

Propranolol

Answer

Beta-blockers such as propranolol are classic pharmacologic causes of telogen effluvium by shifting hairs prematurely from anagen to telogen phase.

American Board of Dermatology (ABD) Practice Test

American Board of Dermatology (ABD) Practice Test

ABD ABD Hair and Nail Disorders 2