AAVSB - American Association of Veterinary State Boards Pharmacology and Toxicology Questions and Answers

Question 1

A 6-year-old male neutered Border Collie is presented with acute onset of seizures, ataxia, and apparent blindness.
The owner reports the dog may have ingested a medication from the barn used to deworm sheep.
Which of the following drugs is the most likely cause of these clinical signs?

Accepted Answer

Ivermectin

Answer

Fenbendazole

Answer

Praziquantel

Answer

Pyrantel pamoate

Question 2

A client calls in a panic stating their 2-year-old cat just ingested several acetaminophen (500 mg) tablets. Which of the following clinical signs and laboratory findings is most characteristic of acetaminophen toxicity in this species?

Accepted Answer

Methemoglobinemia, facial edema, and hepatic necrosis

Answer

Acute renal failure with calcium oxalate crystalluria

Answer

Severe gastrointestinal ulceration and hemorrhage

Answer

Cardiotoxicity and pulmonary edema

Question 3

Which of the following is the primary mechanism of action for non-steroidal anti-inflammatory drugs (NSAIDs) like carprofen and meloxicam?

Accepted Answer

Inhibition of cyclooxygenase (COX) enzymes

Answer

Antagonism of opioid receptors

Answer

Blockade of N-methyl-D-aspartate (NMDA) receptors

Answer

Inhibition of monoamine oxidase (MAO)

Question 4

A horse is being treated with gentamicin, an aminoglycoside antibiotic, for a severe bacterial infection. Which of the following potential toxicities is the most significant concern with this class of drug and requires therapeutic monitoring?

Accepted Answer

Nephrotoxicity

Answer

Hepatotoxicity

Answer

Cardiotoxicity

Answer

Neurotoxicity

Question 5

A dog presents with signs of severe coagulopathy, including epistaxis and melena, 4 days after potentially ingesting a rodenticide. Which of the following is the most likely active ingredient in the rodenticide and the most appropriate antidote?

Accepted Answer

Brodifacoum; Vitamin K1

Answer

Strychnine; Methocarbamol

Answer

Cholecalciferol (Vitamin D3); Calcitonin

Answer

Bromethalin; Methylene blue

Question 6

What is the primary reason for avoiding the use of fluoroquinolone antibiotics (e.g., enrofloxacin) in young, growing puppies?

Accepted Answer

Adverse effects on the development of articular cartilage

Answer

Risk of causing permanent yellow discoloration of the teeth

Answer

Potential to induce Fanconi syndrome, a renal tubular defect

Answer

Association with the development of aplastic anemia

A 6-year-old male neutered Border Collie is presented with acute onset of seizures, ataxia, and apparent blindness.The owner reports the dog may have ingested a medication from the barn used to deworm sheep.Which of the following drugs is the most likely cause of these clinical signs?

A 6-year-old male neutered Border Collie is presented with acute onset of seizures, ataxia, and apparent blindness.
The owner reports the dog may have ingested a medication from the barn used to deworm sheep.
Which of the following drugs is the most likely cause of these clinical signs?